Z704415
Sigma
Bioinformatics and Drug Discovery
| ISBN-10: | 1-58829-346-7 |
| ISBN-13: | 978-1-58829-346-6 |
Description
| General description | A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described. |
Properties
| publication info | R. Larson, Humana Press, 2005, 454 pp., hard cover |
Table Of Contents
| Table of Contents | New Strategies in Drug Discovery Basic Microarray Analysis: Strategies for Successful Experiments From Microarray to Biologic Networks: Analysis of Gene Expression Profiles Microarray Analysis in Drug Discovery and Clinical Applications Ontology-Driven Approaches to Analyzing Data in Functional Genomics Gene Evolution and Drug Discovery Standardization of Microarray and Pharmaocogenomics Data Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics Protein Interactions Probed with Mass Spectrometry Discovering New Drug Targeting Sites on Flexible Multi-Domain Protein Kinases: Combining Segmental Isotopic and Site-Directed Spin Labeling for NMR Dectection of Interfacial Clefts NMR-Based Screening Methods for Drug Discovery Receptor Binding Sites: Bioinformatic Approaches In Silico Protein Design: Fitting Sequence onto Structure Chemical Database Preparation for Compound Acquisition or Virtual Screening Bioinformatics Platform Development: From Gene to Lead Compound |
